How It Works

diagram

SQZ Biotech’s technology – CellSqueeze – is a vector-free platform used for cell delivery. It is actually very simple. It is a microfluidic chip that consists of a series of channels and each one of them has at least one constriction smaller than the cell diameter. The cells – in a culture with the material to be delivered (e.g. proteins, RNA, nanomaterials, DNA…) – are pushed through the channels with pressure. As the cells pass through the constrictions, they get “squeezed”. Due to this gentle squeezing, transient pores open up in the membrane. While the pores are open, the material of interest gets inside the cells by diffusion. After few minutes, the membrane closes and… that’s it. For more details on how CellSqueeze works please watch the video below!

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