CELL SQUEEZING. VECTOR-FREE CYTOSOLIC DELIVERY OF MATERIAL.

How does it COMPARE TO ALTERNATIVE TECHNOLOGIES?

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    Note: The comparison was performed by delivering transcription factors (proteins) for cell reprogramming.
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    Note: Results vary per cell type. Contact SQZ staff for more details.

ENABLES NEW APPLICATIONS

What do we use to squeeze the cells? 3 COMPONENTS

  • RESERVOIR SYSTEM

    The CellSqueeze chip is mounted onto an interface with reservoirs to hold cells before and after squeezing.

  • CELLSQUEEZE CHIPS

    Microfluidic channels with cell deforming features are etched onto silicon chips and sealed with a glass layer. These disposable chips are the functional core of our platform.

  • PRESSURE SYSTEM

    The cells move through the CellSqueeze chip under positive pressure. Our control system ensures uniform flow through the microfluidic channels.

NOT YOUR ONE SIZE FITS ALL APPROACH

Different cell sizes require different constriction geometries. A fibroblast, for example, requires a wider constriction than a naïve T cell. We have 20+ CellSqueeze chip designs with different constriction geometries.

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Did you know? Our current designs can treat > 1,000,000 cells/s